Do Lactation-Induced Changes in Ghrelin, Glucagon-Like Peptide-1, and Peptide YY Influence Appetite and Body Weight Regulation during the First Postpartum Year?
Hindawi Publishing Corporation Journal of Obesity Volume 2016, Article ID 7532926, 11 pages
http://dx.doi.org/10.1155/2016/7532926
By 12 months, lactating women lost 5.3 ± 2.2 kg (n = 18), whereas control women (n = 15) remained weight stable (p = 0.019); fifteen of the lactating women returned to within ±2.0 kg of prepregnancy weight but three retained >6.0 kg. The retainers had greater (p < 0.05) postmeal ghrelin rebound responses following breakfast.
Comparisons between women who returned to within 2 kg of their prepregnancy weight (n = 15) and those that had retained their pregnancy-associated weight gain (n = 3) suggested that those retaining weight had gained more during pregnancy (22.0 ± 5.7 versus 15.0 ± 3.4 kg, p < 0.05) … The weight retainers also had higher fasting insulin … and greater insulin (total AUC, 1299 ± 542 versus 446 ± 362, p < 0.05) and ghrelin rebound responses (i.e., higher response after the initial postmeal fall; positive AUC, 17155 ± 27648 versus 2893 ± 3033, p < 0.05) after the standardized breakfast meal.
Có 3 người giữ >6kg dù cho con bú hoàn toàn trong 18 người mẹ. Những người giữ cân này tăng cân khi mang thai nhiều hơn, và có ghrelin bật lại mạnh hơn sau bữa sáng, nên dễ đói nhanh hơn và khó giảm cân hơn.